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KMID : 0385219970070020047
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Korean Journal of Gerontology
1997 Volume.7 No. 2 p.47 ~ p.51
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Effect of Lipophilic Fraction from Panax ginseng on Phosphatidylinositol Breakdown in Rat Platelets Activated by Collagen
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Park Hwa-Jin
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Abstract
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We have studied the effect of a lipophilic fraction (LF) from Panax ginseng C.A. Meyer on phosphatidylinositol (PI) breakdown in platelets stimulated with collagen. When platelets (109/㎖) prelabeled with [C14]-arachidonic acid (20:4) were stimulated by collagen (20 ㎍/㎖), [C14-20:4]-PI was decreased compared with that of the control, unstimulated platelets. However, [C14-20:4]-PI was increased by an exogenous LF (20 ㎍/㎖). Phosphatidic acid (PA) and [C14-20:4]-metabolites, breakdown-product of phosphoinositides such as PI, phosphatidylinositol-4-monophosphate and phosphatidylinositol 4,5-bisphosphate, were increased in collagen-stimulated platelets. But both [C14-20:4]-PA and [C14-20:4]-metabolites were reversed to the control level by LF added in collagen-stimulated platelet suspension. These results suggested that LF inhibits the breakdown of [C14-20:4]-PI in collagen-stimulated platelets. Thus, our data demonstrates that LF has an antiplatelet effect by inhibiting PI-breakdown.
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KEYWORD
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Panax ginseng, Lipophilic fraction, Phosphatidylinositol, Phosphatidic acid, 20:4-metabolites
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